There is a task-specificity in the visual-tactile interaction for perception: The polymodal posterior parietal cortex is related to the comparison of the shapes coded by different sensory modalities, whereas the lateral occipital complex is the part of the network for multimodal shape identification. These interactions may be mediated by some latent pathways potentiated by sensory deprivation or learning.

La présente étude examine comment les intellectuels japonais tentèrent d’introduire l’utilitarisme lors du premier stade d’un processus de modernisation dans la seconde moitié du XIXe siècle. Elle décrit les efforts significatifs qu’ils consacrèrent à la traduction des œuvres ou des textes de Bentham et de Mill en créant de nombreux mots japonais nouveaux. Car, jusqu’à la fin de la société agraire quasi féodale du shogunat Tokugawa, il n’y avait quasiment pas eu de concepts équivalents pour des notions telles que l’individu, (...) la liberté, le droit, la démocratie, par exemple. La Restauration de Meiji de 1868, au premier abord, suggère par son nom une restauration de l’ancien régime ; mais en réalité c’était l’inverse, car il s’agissait d’un tournant décisif pour le Japon, dont le but était d’établir une nouvelle société industrielle moderne. La présente recherche fournit tout d’abord une liste chronologique des traductions des œuvres de Bentham et Mill réalisées au cours des deux premières décennies après la Restauration. Ensuite, elle évalue la précision et la validité du résultat de la traduction, en prenant comme exemple le premier paragraphe de l’Introduction aux Principes de la Morale et de la Législation. En troisième lieu, elle examine dans quelle mesure les intellectuels japonais de cette époque comprirent l’utilitarisme dans le processus de création des nouvelles traductions en japonais. Ce processus était issu de la tradition consistant à créer différents concepts japonais uniques, sous forme de mots composés de caractères hiéroglyphiques chinois, ancrés profondément dans l’influence culturelle du confucianisme qui domina longtemps à partir du VIe siècle. Enfin, la présente étude évalue comment les premières présentations de Bentham et Mill influencèrent la génération suivante d’intellectuels japonais. Ce résultat peut expliquer dans une certaine mesure pourquoi le Japon ne compte démographiquement que 0,8 % de chrétiens, et pourquoi la société japonaise est fondamentalement laïque et tournée vers le succès économique. (shrink)

There are various philosophers who have discussed the role of language in ancient India. Among them, Bhart ṛ hari considered the relation between the superficial appearance of speech and its essential nature. In actual life, we pronounce and perceive the word. He held that there must be some link between ideal logic and worldly truth. His focus in the Brahmakā n ̣ ḍ a of the Vākyapadīya, is on the process of communication, the process of the internalization of speech. He (...) differentiates the perspective of the speaker and the hearer, and explains the movement of sounds. The spho ṭ a theory addresses both how to pronounce the word and how to perceive it. Traces of his discussion are found in the works of his follower Ma n ̣ ḍ anamiśra in his book, Spho ṭ asiddhi. (shrink)

自由仿成立仿先主、因果必然性別支配寸物質立異急次元、心旬次元力開力、才主巴拉、。茫力心比月自由仗、哥才力可銷貨可月可能性主共比的均可能。旬可能性旬僵北』乙、心的主体私自己妙、旁的成立原理自己中心化才叫 是己扒拉姆現象芒主是很本力、已耘倒芝址、拳己才老他者差向吵早已行為主的愛力可位值寸之已。吃力可愛怯、自由主不可分仿錯覺仿可能性比起日是、哥仿「他者的可思、自体別儀接芒才先自己漪足可能性是弘拭壹放心。才 包銷貨仿己仿二重仿嫌疑位也拘色字、愛仿可能性自体力可損急才己主怒、。自由位也增困難慈愛怯、陣、芝才也仍，、花力可司仿限可能競月。 Pour que la liberté s'établisse à un autre niveau que celui des choses régies par la nécessité causale, il faut le niveau de l'âme. Mais la liberté n'est possible qu'accompagnée de multiples illusions. Or, l' amour est l'acte du sujet de l'âme : il s'offre totalement à l'autre en renversant radicalement son principe de fondation qui est l'autocentration. Par conséquent, l' amour se situe aux confins imprenables de la possibilité d'illusions qui accompagnent la liberté. De plus, l' amour est (...) toujours menacé par la possibilité masquée de l'autosatisfaction. Cependant, cette double suspicion d'illusion n'anéantit pas la possibilité de l' amour. L' amour, qui est encore plus difficile que la liberté, reste possible comme ce qui est caché et à condition d'être caché. So that freedom may rests itself on another level than that of things governed by causal necessity, one needs necessarily to refer to the level of the soul. But freedom is possible only accompanied with multiple illusions. Now love is the act of the subject of the soul: it offers itself totally to the other one by knocking down radically his principle of foundation which is the self-centeredness. Consequently love is situated in the impregnable borders of the possibility of illusions which go along freedom. Furthermore, love is always threatened by the masked possibility of self-satisfaction. However this double suspicion of illusion does not annihilate the possibility of love. Love, which is even more difficult than freedom, remains liable as what is hidden and on the condition of its being hidden. (shrink)

Everyday aesthetic experiences and concerns occupy a large part of our aesthetic life. However, because of their prevalence and mundane nature, we tend not to pay much attention to them, let alone examine their significance. Western aesthetic theories of the past few centuries also neglect everyday aesthetics because of their almost exclusive emphasis on art. In a ground-breaking new study, Yuriko Saito provides a detailed investigation into our everyday aesthetic experiences, and reveals how our everyday aesthetic tastes and judgments (...) can exert a powerful influence on the state of the world and our quality of life. By analysing a wide range of examples from our aesthetic interactions with nature, the environment, everyday objects, and Japanese culture, Saito illustrates the complex nature of seemingly simple and innocuous aesthetic responses. She discusses the inadequacy of art-centered aesthetics, the aesthetic appreciation of the distinctive characters of objects or phenomena, responses to various manifestations of transience, and the aesthetic expression of moral values; and she examines the moral, political, existential, and environmental implications of these and other issues. (shrink)

Some of the basic substructural logics are shown by Ono to have the disjunction property (DP) by using cut elimination of sequent calculi for these logics. On the other hand, this syntactic method works only for a limited number of substructural logics. Here we show that Maksimova's criterion on the DP of superintuitionistic logics can be naturally extended to one on the DP of substructural logics over FL. By using this, we show the DP for some of the substructural logics (...) for which syntactic methods don't work well. (shrink)

Firstly I characterize Simple Partial Logic (SPL) as the generalization and extension of a certain two-valued logic. Based on the characterization I present two definitions of validity in SPL. Finally I show that given my characterization these two definitions are more appropriate than other definitions that have been prevalent, since both have some desirable semantic properties that the others lack.

The epistemological chasm between how we (implicitly and subjectively) perceive or imagine the actual world and how we (explicitly and “objectively”) think of its underlying entities has motivated perhaps the most disconcerting impasse in human thought: the explanatory gap between the phenomenal and physical properties of the world. Here, I advocate a combination of philosophical skepticism and simplicity as an informed approach to arbitrate among theories of consciousness. I argue that the explanatory gap is rightly a gap in our understanding, (...) but one that is not surprising; and we being observers biased by our first-person perspective and our existence may both hinder and (the realization we have them) assist our reasoning. Further, I unfold the concept of observer into two distinct notions based on its functional and phenomenal aspects, and exploit this device to elucidate the subject-observer relationship. Then, I proceed to analyze the philosophical zombie dilemma. Lastly, I contend that from a skeptical viewpoint, panpsychism (or neutral monism) is the most parsimonious doctrine accounting for the explanatory gap, and suggest that it would be possible to make headway in the hard problem of consciousness by uncovering non-trivial causal relationships between qualia states and functional states, if routine and controlled manipulation of neural circuits were easily available. (shrink)

The Drosophila compound eye is an excellent experimental system for analysing fate induction of identifiable single cells. Each ommatidium, a unit eye, contains eight photoreceptors (R1‐R8), and the differentiation of these photoreceptors occurs in the larval eye imaginal disc in discrete steps: first R8 is determined, then R2/R5, R3/R4, R1/R6 and finally R7. Induction of R7, in particular, has been extensively studied at the molecular level. The R8 photoreceptor presents on its surface a ligand, Bride of Sevenless, that binds and (...) activates Sevenless receptor tyrosine kinase in the R7 precursor. Autophosphorylated Sevenless initiates a Ras1‐mediated cascade, which eventually activates transcription factors in the nucleus via Raf1 and MAP kinases, resulting in R7 development. However, recent studies indicate that Sevenless (Sev) functions just to neuralize the cell and has no role in R7 fate determination per se. It appears that the R7 fate may represent the lowest rung of a ‘neuronal ground state’, which is attained without any specific inductive cue. It is plausible that the R7 precursor is actively prevented from taking on the neuronal fate and this inhibition is removed by activation of Sev. (shrink)

To apply reinforcement learning to difficult classes such as real-environment learning, we need to use a method robust to perceptual aliasing problem. The exploitation-oriented methods such as Profit Sharing can deal with the perceptual aliasing problem to a certain extent. However, when the agent needs to select different actions at the same sensory input, the learning efficiency worsens. To overcome the problem, several state partition methods using history information of state-action pairs are proposed. These methods try to convert a POMDP (...) environment into an MDP environment, and thus they are sometimes very useful. However, their computation cost is very high especially in large state spaces. In contrast, memory-less approaches try to escape from the aliased states by outputting actions stochastically. However, these methods output actions stochastically even in unaliased states, and thus the learning efficiency is bad. If we desire to guarantee the rationality in POMDPs, it is efficient to output actions stochastically only in the aliased states and to output one action deterministically in the other unaliased states. Hence, to discriminate between aliased states and unaliased states, the utilization of χ² -goodness-of-fit test is proposed by Miyazaki et al. They point out that, in aliased states, the distributions of the state transitions by random search and a particular policy are different. This difference doesn't occur owing to non-deterministic actions. Hence, if the agent can collect enough samples to implement the test, the agent can distinguish between aliased states and unaliased states well. However, such a test needs a large amount of data, and it's a problem how the agent collects samples without worsening learning efficiency. If the agent uses random search in the course of learning, the learning efficiency worsens especially in unaliased states. Therefore, in this research, we propose a new method called Extended On-line Profit Sharing with Judgement (EOPSwJ) to detect important incomplete perception, which doesn't need large computation cost and numerous samples. We use two criterions for detecting important incomplete perceptions to attain a task. One is the rate of transitions to each state, and the other is the deterministic rate of actions. We confirm the availability of EOPSwJ using two simulations. (shrink)

Actions shape what we see and memorize. A previous study suggested the interaction between motor and memory systems by showing that memory encoding for task-irrelevant items was enhanced when presented with motor-response cues. However, in the studies on the attentional boost effect, it has been revealed that detection of the target stimulus can lead to memory enhancement without requiring overt action. Thus, the direct link between the action and memory remains unclear. To exclude the effect of the target detection process (...) as a potential confounder, this study assessed the benefit of action for memory by separating items from the response cue in time. In our pre-registered online experiment, participants responded to visual Go cues by pressing a key or counting while ignoring No-go cues. In each trial, two task-irrelevant images were sequentially presented after the cue disappearance. After encoding the Go/No-go tasks, participants performed a surprise recognition memory test for those images. Importantly, we quantified the impact of overt execution of the action by comparing memories with and without motor response and the impact of covert motor processes by comparing memory between the motor and cognitive tasks. The results showed no memory differences between Go and No-go trials in the motor task. This means that the execution itself was not critical for memory enhancement. However, the memory performance in the motor No-go trials was higher than that in the cognitive No-go trials, only for the items presented away from the cues in time. Therefore, engaging the motor task itself could increase incidental memory for the task-irrelevant items compared to a passive viewing situation. We added empirical evidence on the online interaction between action and memory encoding. These memory advantages could be especially brought in action preparation and planning. We believe this fact may expand our present understanding of everyday memory, such as active learning. (shrink)

We propose a novel algorithm to transliterate English to Japanese and its application to a voice controlled browser, which enable ordinary Japanese people to browse English Web site by voice. Speech recognition software designed for native English speakers do not work for most Japanese because Japanese can't pronounce English as native English speakers do. Therefore, we combined Japanese speech recognition software with English-to-Japanese transliteration software. The accuracy of our transliteration algorithm is 80% recall for the top candidate, and 92% recall (...) for the top three candidates. The browser using this transliteration algorithm makes it possible for Japanese to navigate English Web pages almost as accurate as Japanese pages by voice commands. (shrink)

For a large natural class of forcing notions, we prove general equivalence theorems between forcing absoluteness statements, regularity properties, and transcendence properties over and the core model . We use our results to answer open questions from set theory of the reals.

Despite the police preventing special fraud victimisation of older adults, both the number of cases and the amount of damage have remained high in Japan. ‘Special fraud’, in Japan, is a crime in which victims are tricked by fraudsters who through phone or postcards impersonate the victims’ relatives, employees and other associates, to dupe the victims of their cash or other valuables. The number of recognised cases of special fraud has been turned to increase in 2021. Although police or consumer (...) affairs administrations have been conducting all-encompassing enlightenment or public education for prevention, it is also necessary to reach out to those who are vulnerable to fraud. In this study, we determine the psychosocial characteristics of victims of special fraud in Japanese older adults. We analysed the age, gender, education, residential status, household satisfaction, risk perception and scam vulnerability scale of 56 older adults aged 60 years or older who had been victims of special fraud and 99 older adults aged 60 years or older who had never been victims of special fraud. The study found that the victimised older adults were more likely to be females who live alone and go out less frequently than the non-victimised older adults. The total scores of the scam vulnerability scale were higher among the elderly victims of special fraud compared to those who had never been scammed, suggesting that the psychosocial characteristics of victims of special fraud among older adults are being female, living alone, going out infrequently, having high confidence against fraud victimisation and responding quickly to phone calls and unknown visitors. Therefore, government agencies or family members should take care of older women who meet these characteristics to reduce their contact with fraudsters. (shrink)

In so-called full second-order logic, the second-order variables range over all subsets and relations of the domain in question. In so-called Henkin second-order logic, every model is endowed with a set of subsets and relations which will serve as the range of the second-order variables. In our Boolean-valued second-order logic, the second-order variables range over all Boolean-valued subsets and relations on the domain. We show that under large cardinal assumptions Boolean-valued second-order logic is more robust than full second-order logic. Its (...) validity is absolute under forcing, and its Hanf and Löwenheim numbers are smaller than those of full second-order logic. (shrink)

The purpose of this paper is to investigate the relationship between collective rationality and permissible collective choice rules using a unified approach inspired by Bossert and Suzumura (J Econ Theory 138:311–320, 2008). We consider collective choice rules satisfying four axioms: unrestricted domain, strong Pareto, anonymity, and neutrality. A number of new classes of collective choice rules as well as the Pareto and Pareto extension rules are characterized under various concepts of collective rationality: acyclicity, transitivity, quasi-transitivity, semi-transitivity, and the interval order (...) property. Further, new concepts of collective rationality, K-term acyclicity and K-term consistency, are proposed and the corresponding characterizations are provided. (shrink)

Recently, many opportunities have emerged to use the Internet in daily life and classrooms. However, with the growth of the World Wide Web (Web), it is becoming increasingly difficult to find target information on the Internet. In this study, we explore a method for developing the ability of users in information seeking on the Web and construct a search process feedback system supporting reflective activities of information seeking on the Web. Reflection is defined as a cognitive activity for monitoring, evaluating, (...) and modifying one's thinking and process. In the field of learning science, many researchers have investigated reflective activities that facilitate learners' problem solving and deep understanding. The characteristics of this system are: (1) to show learners' search processes on the Web as described, based on a cognitive schema, and (2) to prompt learners to reflect on their search processes. We expect that users of this system can reflect on their search processes by receiving information on their own search processes provided by the system, and that these types of reflective activity helps them to deepen their understanding of information seeking activities. We have conducted an experiment to investigate the effects of our system. The experimental results confirmed that (1) the system actually facilitated the learners' reflective activities by providing process visualization and prompts, and (2) the learners who reflected on their search processes more actively understood their own search processes more deeply. (shrink)

Besides sensory characteristics of food, food-evoked emotion is a crucial factor in predicting consumer’s food preference and therefore in developing new products. Many measures have been developed to assess food-evoked emotions. The aim of this literature review is (i) to give an exhaustive overview of measures used in current research and (ii) to categorize these methods along measurement level (physiological, behavioral, and cognitive) and emotional processing level (unconscious sensory, perceptual / early cognitive, and conscious / decision making) level. This 3x3 (...) categorization may help researchers to compile a set of complementary measures (‘toolbox’) for their studies. We included 101 peer-reviewed articles that evaluate consumer’s emotions and were published between 1997 to 2016, providing us with 59 different measures. More than 60% of these measures are based on self-reported, subjective ratings and questionnaires (cognitive measurement level) and assess the conscious / decision-making level of emotional processing. This multitude of measures and their overrepresentation in a single category hinders the comparison of results across studies and building a complete multi-faceted picture of food-evoked emotions. We recommend (1) to use widely applied, validated measures only, (2) to refrain from using (highly correlated) measures from the same category but use measures from different categories instead, preferably covering all three emotional processing levels, and (3) to acquire and share simultaneously collected physiological, behavioral, and cognitive datasets to improve the predictive power of food choice and other models. (shrink)

We study various classes of maximality principles, \\), introduced by Hamkins :527–550, 2003), where \ defines a class of forcing posets and \ is an infinite cardinal. We explore the consistency strength and the relationship of \\) with various forcing axioms when \. In particular, we give a characterization of bounded forcing axioms for a class of forcings \ in terms of maximality principles MP\\) for \ formulas. A significant part of the paper is devoted to studying the principle MP\\) (...) where \ and \ defines the class of stationary set preserving forcings. We show that MP\\) has high consistency strength; on the other hand, if \ defines the class of proper forcings or semi-proper forcings, then by Hamkins, MP\\) is consistent relative to \. (shrink)

This paper considers methodological issues of awareness during adult second language acquisition. Specifically, the paper deals with the issue of instructional orientations, the issue of biases in knowledge measurement, and the issue of reactivity in the online think-aloud protocol. Detailed reviews of prominent SLA research that has investigated the possibility of implicit SLA reveal that the instruction on implicit learning does not guarantee that learners engage in the implicit learning mode, that the majority of SLA research has employed only tests (...) of “explicit learning” such as untimed grammaticality judgment, and that there is some evidence that the online think-aloud protocol causes negative reactivity particularly when it is metalinguistic in nature. (shrink)

Methodological problems of how awareness during learning should be measured have been extensively discussed and investigated in cognitive psychology. This review considers; 1)whether amnesics can perform implicit learning tasks at a similar level to normal controls, 2) whether differences in instructional orientations create dissociations in performance in tests of implicit and explicit knowledge, and 3) whether participants can retrospectively verbalise the learning outcomes. The paper concludes that; amnesics’ implicit learning abilities differ from the normal controls, instructions on implicit learning do (...) not guarantee the occurrence of implicit learning, and objective and subjective awareness measures used in the literature face inherent problems and so the awareness controversy remains unsettled. (shrink)

The involvement of nitric oxide in cerebellar long-term depression is supported by the observation that nitric oxide is released by climbing fiber stimulation and by pharmacological tool usage. Two forms of long-term depression should be distinguished by their physiological relevance. [CRÉPEL et al.; LINDEN; VINCENT].

As a criterion of a good firm, a lucrative and growing business has been said to be important. Recently, however, high profitability and high growth potential are insufficient for the criteria, because social influences exerted by recent firms have been extremely significant. In this paper, high social relationship is added to the list of the criteria. Empirical corporate social performance versus corporate financial performance (CSP–CFP) relationship studies that consider social relationship are very limited in Japan, and there are no definite (...) conclusions for the studies in the world, because of scant data and the inappropriate methods, especially for supporting linear hypothesis which these studies are based on. In this paper, the CSP–CFP relationship is analyzed by an artificial neural networks model, which can deal with a non-linear relationship, using 10-year follow-up survey data. (shrink)

BackgroundThe concept of career identity is integral to nursing practices and forms the basis of the nursing professions. Positive career identity is essential for providing high-quality care, optimizing patient outcomes, and enhancing the retention of health professionals. Therefore, there is a need to explore potential influencing variables, thereby developing effective interventions to improve career identity.ObjectivesTo investigate the relationship between moral distress, moral courage, and career identity, and explore the mediating role of moral courage between moral distress and career identity among (...) nurses.DesignA quantitative, cross-sectional study.MethodsA convenient sample of 800 nurses was recruited from two tertiary care hospitals between February and March 2022. Participants were assessed using the Moral Distress Scale-revised, Nurses’ Moral Courage Scale, and Nursing Career Identity Scale. This study was described in accordance with the STROBE statement.Ethical considerationResearch ethics approval was obtained from the researcher’s university and hospital where this study was conducted prior to data collection.FindingsMoral distress is negatively associated while moral courage is positively associated with career identity among nurses. Moral courage partially mediates the relationship between moral distress and career identity ( β = −0.230 to −0.163, p < 0.01).DiscussionThe findings reveal a relationship between moral distress, moral courage, and career identity among nurses.ConclusionBy paying attention to nurses’ moral distress and courage, healthcare providers can contribute to the development of effective interventions to improve career identity, and subsequently performance, among nurses. (shrink)

In this study, we discuss the psychological acceptability of an utterance strategy used by the Driving Support Agent. Previous literature regarding DSA suggests that the adoption of a small robot as a form will increase acceptability. However, the agent’s utterance has been reported as a problem faced by the user. Therefore, in this study, we designed the agent’s utterance using politeness strategy as described by Brown and Levinson’s famous sociolinguistics and pragmatics theory and analyzed its acceptability through a participant-based experiment. (...) In this experiment, we used positive and negative politeness strategies. In general, PPS is utilized to reflect the desire to be liked/recognized by others, whereas NPS is utilized to reflect the need for not wanting to be disturbed by others. Based on our results, PPS was rated high compared to NPS. Therefore, many participants highly evaluated PPS. However, there was a group of participants who appreciated NPS. There were also participants who evaluated the two strategies equally. The number of participants in these three groups was observed at 4:1:1. This result contributes as an index on the utterance design of the DSA. (shrink)

We show under that every set of reals is I‐regular for any σ‐ideal I on the Baire space such that is proper. This answers the question of Khomskii [7, Question 2.6.5]. We also show that the same conclusion holds under if we additionally assume that the set of Borel codes for I‐positive sets is. If we do not assume, the notion of properness becomes obscure as pointed out by Asperó and Karagila [1]. Using the notion of strong properness similar to (...) the one introduced by Bagaria and Bosch [2], we show under without using that every set of reals is I‐regular for any σ‐ideal I on the Baire space such that is strongly proper assuming every set of reals is ∞‐Borel and there is no ω1‐sequence of distinct reals. In particular, the same conclusion holds in a Solovay model. (shrink)

We show that ${{\bf \Sigma}^1_3}$ -absoluteness for Sacks forcing is equivalent to the non-existence of a ${{\bf \Delta}^1_2}$ Bernstein set. We also show that Sacks forcing is the weakest forcing notion among all of the preorders that add a new real with respect to ${{\bf \Sigma}^1_3}$ forcing absoluteness.

The theory of infinite games with slightly imperfect information has been developed for games with finitely and countably many moves. In this paper, we shift the discussion to games with uncountably many possible moves, introducing the axiom of real Blackwell determinacy \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathsf{Bl-AD}_\mathbb{R}}$$\end{document} (as an analogue of the axiom of real determinacy \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathsf{AD}_\mathbb{R}}$$\end{document}). We prove that the consistency strength of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} (...) \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathsf{Bl-AD}_\mathbb{R}}$$\end{document} is strictly greater than that of AD. (shrink)

Sustained peripheral somatosensory stimulations, such as high-frequency repetitive somatosensory stimulation (HF-RSS) and vibrated stimulation, are effective in altering the balance between excitation and inhibition in the somatosensory cortex (S1) and motor cortex (M1). A recent study reported that whole-hand water flow (WF) stimulation induced neural disinhibition in the M1. Based on previous results, we hypothesized that whole-hand WF stimulation would lead to neural disinhibition in the S1 because there is a strong neural connection between M1 and S1 and aimed to (...) examine whether whole-hand WF stimulation would change the neural balance between excitation and inhibition in the S1. Nineteen healthy volunteers were studied by measuring excitation and inhibition in the S1 before and after each of the four 15-min interventions. The excitation and inhibition in the S1 were assessed using somatosensory evoked potentials (SEPs) and paired-pulse inhibition (PPI) induced by single- and paired-pulse stimulations, respectively. The four interventions were as follows: control, whole-hand water immersion, whole-hand WF, and HF-RSS. The results showed no significant changes in SEPs and PPI following any intervention. However, changes in PPI with an interstimulus interval (ISI) of 30 ms were significantly correlated with the baseline value before whole-hand WF. Thus, the present findings indicated that the whole-hand WF stimulation had a greater decreased neural inhibition in participants with higher neural inhibition in the S1 at baseline. Considering previous results on M1, the present results possibly show that S1 has lower plasticity than M1 and that the duration (15 min) of each intervention may not have been enough to alter the balance of excitation and inhibition in the S1. (shrink)

The BTB domain is a protein–protein interaction motif that is found throughout eukaryotes. It determines a unique tri‐dimensional fold with a large interaction surface. The exposed residues are highly variable and can permit dimerization and oligomerization, as well as interaction with a number of other proteins. BTB‐containing proteins are numerous and control cellular processes that range from actin dynamics to cell‐cycle regulation. Here, we review findings in the field of transcriptional regulation to illustrate how the high variability of the BTB (...) has allowed related transcription factors to evolve different functional abilities. We then report how recent work has showed that, in spite of their high sequence divergence and apparently unrelated functions, many BTB‐containing proteins have at least one shared role: the recruitment of degradation targets to E3 ubiquitin ligase complexes. Taken together, these findings illustrate diverse and convergent functions of a versatile protein–protein interaction domain. BioEssays 28: 1194–1202, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

狂信的な国粋主義者か、はたまた魂の尊厳を問うた求道者か。民俗学と国粋主義の親和性とは。多角的な視点からファシズムを再考する。.